Astragal bu am membranaas, ñax mudul jeex ci famiy Leguminosae, dafay jëfandikoo reenam gu waw ngir faj ko. Ci pajum cosaanu waa Chine (TCM), liggéeyam bu mag mooy "tonif Qi ak dëgëral biti," te dañu koy faral di jëfandikoo ci màndarga yu melni ñàkkum Qi, coono, ñaq ci saasi, ñaq guddi, ak ñàkka mëna jàpp pathogen yi ci biti. Baatu"Qi"ci TCM ab gis-gis abstrait la buy jëfandikoo, lu ci melni li muy tekki dafay jaxasoo bu baax ak li medsin bu bees bi di woowe"immunite." Polisakarid AstragalBioactif bi njëkk ci Astragalus mooy joxe fundamaasu science ngir tekki xalaatu TCM ci "Qi tonification" ci konsepti yu bees yu melni jàppale immuniteer, ndax seen dooley immunomodulateur, antioxydant, ak liggéey yuy tere coono [1].
Ci atum 2023, komite bu mag bi yor wàllum paj ci Chine genne na ab yëgle bu n°. 9, di nangu Astragalus, Codonopsis, ak juróom ñaari yeneen mbir ñu boole leen ci limu mbir yi ñuy faral di jëfandikoo ci cosaan ak ci garab, suko defee ñu gëna mëna jëfandikoo.
(Nataal bi: Komite Nasionaal bu Wérgi-yaram bu Republik Populeer bu Chine)
Doonte polisakkarid yu Astragalus (APS) ñooy lëf yi gëna am solo ci Astragalus, mbàq nit ñi amul enzyme yiy reesal yi war ngir hydrolyse polisakkarid yu jafee xam yooyu. APS macromoleculaire yi ñuy am ci pexe yiñ gëna xam mënu ñu jàll epitelium bu mbàq yi, moo waral absorption bi daa néew lool. Lu tuuti rek mooy dugg ci circulation systemique bi, te loolu mooy sabab bi tax seen biodisponibilité néew.
- Fermentation ci garabi cosaan yu waa Chine
Rëyaayu polysaccharides yu Astragalus yi dañuy des ci biir mbàq yi, ndax duñu mëna xëcci bu baax. Doxalin yu mag yi am ci jamono jii dañuy wane ni APS dafay nuru benn xeetuprebiyotik. Seen njeexital ajuwul ciabsorbé, waaye cidi fermenter. APS dafay nekk substrat ngir mikrobe yiy lekk ci biir, bakteri yu am njariñ yi ñoo koy soppi, loolu mooy gëna yokk seen bioavailability [2].
Fermentation microbienne ci jumtukaayi pajum chinois dafay màndargaal "kristalisasioŋ bu xam-xam cosaan." Pexem togg yi fi yàgg a nekk dañu daan jëfandikoo ay micro-organisme yuy jaxasoo ak ñax ngir mëna def lu melni "wàññi toxisite, gëna am njariñ, ak soppi màndarga yi ci wàllu paj." Ci core bi, anam yii dañuy wanelëkkaloo gi am ci digganté metabolism mikrobe ak ñax. Fermentation microbien wuute na ak togg yiñ gëna xam (lu melni, toggu, lakk) wala togg chimik (lu melni, bineegar-frite, vin-frite), fermentation microbien dafa am ñatti njariñ yu mag:Reaction bu woyof, jubluwaay bu dëgër, ak bariwaayu produit.
Fermentasioŋ Mikrobial dafay yokk lu ëpp absorpsioŋ
Processus fermentation dafay dox ni xeetu fermentation bu xarañ-reesal. Ay sox probiotik dañuy génne ay enzyme yuy "xar" APS yu am poids moleculaire bu kawe ci ay fragment polysaccharide yu am poid moleculaire bu néew. Njariñ li gëna am solo ci coppite bii mooyyokkute bu am solo ci absorption, may komposant yiy dox ñu mëna dugg ci circulation systemique bi ci anam wu gëna xéewale.
Waaye, njariñu fermentation yamul ci gëna mëna xëcci. Gëstu yi dañu wane ni xeetu molecule yu woyof yi ñuy defaree fermentation microbienne ñooysiñaal immunostimulatër yu am solo. Buñu ko méngale ak APS macromoleculaire, fragment yu ndaw yi ñoo gëna am immunité bu gëna baax ci xàmmee ak bioactivité bu gëna am doole. Dañu gëna mëna soppi liggéeyu macrophages yi, lymphocytes T yi, ak yeneen selul immunitaire yu am solo, loolu dafay wane njariñ yu am solo ci yamale homeostasis immunitaire ak gëna mëna kaaraange njaatige [3].
Jàngat yu bari dañu wane nipolysaccharides yu am poids moleculaire bu woyof dañuy wane kàttanu immunologik bu gëna am doole. Ci misaal:
Polysaccharides ginseng yu ndaw yi (10.2 kDa) ñoo gëna am kàttan ci macrophage yi suñu leen méngale ak seeni moroomi molecule yu kawe yi (21.3 kDa) [4];
Glycerrhiza polysaccharides (GP) yu am poid bu woyof dañu am njeexital yu baax ci yamale immuniteeru mbàq yi [5];
Yeneen polysaccharides yu am doole ci champignon yi,Pueraria lobata, ak yeneen balluwaay yu noonu mel itam dañuy wane liggéey bu baax ci biir ay molecule -poids [6].
Buñu leen boole, li ñu gis dafay wane nicër bu mag bi ci wàññi poids moleculaire -ci yokk kàttanu immunomodulatëru polisakariid yi.
